Felodipin Stada 5/10 Retard Drug Interactions

Felodipine is metabolised in the liver by cytochrome P450 3A4 (CYP3A4); hence, interactions may occur if concomitantly administrated with felodipine.
With other drugs sharing the same metabolic partway (e.g. quindine (felodipine plasma concentration increase), diltiazem (felodipine plasma concentration increase), tacrolimus (tacrolimus exposure increase)).
With enzyme inducers (phenytoin, carbamazepine, phenobarbital, rifampicin, barbiturates, efavirenz, nevirapine, St. John's wort). These interactions lead to decreased plasma concentration of felodipine.
With enzyme inhibitors (verapamil, cimetidine, erythromycin, itraconazole, ketoconazole, HIV protease inhibitors, non-nucleoside reverse transcriptase inhibitors, quinupristin, dalfopristin, ethanol, nefazodone, grapefruit juice). These interactions lead to increased plasma concentration of felodipine.
β-Adrenergic blocking agents (propranolol, timolol): The risk of severe hypotension, exacerbation of angina, congestive heart failure and arrhythmia may be increased.
Fentanyl: Severe hypotension has occurred during surgery in patients receiving felodipine, a β-Adrenergic blocking agent and fentanyl concomitantly.
Digoxin: The serum digoxin concentrations may increase.
Hypotensive agents: Concomitant administration of felodipine with hypotensive agents (e.g. methyldopa, hydralazine, captopril, doxazosin) may increase the incidence of severe hypotension.